School of Basic and Applied Science

Centre for Biochemistry and Microbial Sciences


The Centre for Biochemistry and Microbial Sciences within the School of Basic and Applied Sciences started as an independent center in 2015 with an aim to train the students in the fields of biochemistry and microbiology and to encourage interdisciplinary activities among the faculty. The Centre has internationally trained faculty with wide research and teaching experience. The Centre is currently engaged in active research and with several research projects funded by various funding agencies such as DST and DBT. The centre aims to explore and understand the biochemical/molecular basis of life and its role in the disease process and pathogenesis. The centre also plans to get involved in the various social activities and will be guiding the industries at various fronts with respect to microbial applications, development of green technologies and novel drugs. The centre plans to impart specialized training to microbiologists and biochemists from pharmaceutical and food industries as well as agriculture and environmental sectors. The students getting admitted to various programmes of the centre will have excellent opportunities to explore the dynamic fields of biomedical including clinical biochemistry, immune-pharmacology, industrial immunology, and drug research.

Research Thrust Areas

  1. Cancer Biology
  2. Medical Biology
  3. Immunology
  4. Plant Biochemistry and Molecular Biology
  5. Genomics,Proteomics and Metabolomics

Faculty

  1. Dr. Ramakrishna Wusirika, Professor, Centre Coordinator
  2. Dr. Monisha Dhiman, Associate Professor
  3. Dr. Malkhey Verma, Associate Professor
  4. Dr. Somesh Baranwal, Assistant Professor
  5. Dr. Shashank Kumar, Assistant Professor
  6. Dr. Pramod Kushawaha, Assistant Professor
  7. Dr. Manju Jain,DST-SERB Fast Track Fellow

Academic Programmes Offered

  1. Ph.D. Biochemistry and Microbial Sciences
  2. M. Sc. Life Sciences with specialization in Biochemistry
  3. M. Sc. Life Sciences with specialization in Microbial Sciences

Syllabi

2016-17

2015-16

Research Highlights/ Areas

  • Role of metal resistant bacteria and mycorrhiza in enhancing plant growth and metal uptake by modulating metabolic pathways
  • Rice callus suspension culture as an anti-cancer agent against colon, lung, and renal cancer cell lines
  • Plant natural products
  • Chemotherapy induced toxicity
  • Signaling pathways during Inflammation and oxidative stress in various human diseases
  • Drug and vaccine development Visceral Leishmaniasis(Kalazar).
  • Autonomous immunity driven by interferon gamma signalling.
  • Tumour supressor function of Nishcharin in breast cancer
  • Role of cytoplasmic action isoforms in gastrointestinal
  • barrier function.

Laboratory

The centre has access to well-equipped teaching and research laboratories with the following equipment:
  • Ultra-low temperature freezers
  • Centrifuge
  • Microscopes
  • Water Bath
  • Refrigerators
  • Cell culture facility
  • CO2  incubators
  • Laminar air flow cabinets
  • PCR machines
  • Real-time PCR
  • DNA sequencer
  • Gel documentation system

The centre also has access to the following equipment in the Central Instrumentation Laboratory (CIL):

  • Confocal Microscope
  • Scanning Electron Microscope
  • GC-MS
  • UHPLC
  • Flow Cytometer
  • Atomic Absorption Spectrometer
  • Fourier Transform Infrared Spectrometer

Publication

Dr. Ramakrishna Wusirika, Professor, Centre Coordinator
Peer-reviewed Research Publications

  • Dhawi F, Datta R, Ramakrishna W. (2015) Mycorrhiza and PGPB modulate maize biomass, nutrient uptake and metabolic pathways in maize grown in mining-impacted soil. Plant Physiology and Biochemistry 97:390-399. Impact Factor 3.3
  • Dhadi SR, Xu Z, Shaik R,  Driscoll K, Ramakrishna W. (2015)  Differential regulation of genes by retrotransposons in rice promoters. Plant Molecular Biology 87:603-613. Impact Factor 4.3
  • Li K, Pidatala VR, Shaik R, Datta R, Ramakrishna W. (2014) Integrated metabolomic and proteomic approaches dissect the effect of metal resistant bacteria on maize biomass and copper uptake.  Environmental Science and Technology 48:1184–1193. Impact Factor 5.3
  • Shaik R, Ramakrishna W.  (2014) Machine learning approaches distinguish multiple stress conditions using stress-responsive genes and identify candidate genes for broad resistance in rice. Plant Physiology 164:481-495. Impact Factor 8
  • Shaik R, Ramakrishna W. (2013) Genes and coexpression modules common to drought and bacterial stress responses in Arabidopsis and rice.  PloS One 8:e77261. Impact Factor 3.2
  • Dhadi SR, Deshpande A, Driscoll K, Ramakrishna W. (2013) Major cis-regulatory elements for rice bidirectional promoter activity reside in the 5’-untranslated regions. Gene 526:400–410. Impact Factor 2.1
  • Rafi S, Ramakrishna W.  (2012) Bioinformatic analysis of epigenetic and microRNA mediated regulation of drought responsive genes in rice. PloS One 7:e49331. Impact Factor 3.2
  • Li K, Pidatala RR, Ramakrishna W.  (2012) Mutational, proteomic and metabolomic analysis of a plant growth promoting copper-resistant Pseudomonas spp. FEMS Microbiology Letters 335:140–148. Impact Factor 2.1
  • Deshpande AD, Dhadi SR, Hager E, Ramakrishna W.  (2012) Rice callus suspension cultures inhibit growth of two cancer cell lines. Phytotherapy Research 26:1075–1081. Impact Factor 2.7
  • Krom N, Ramakrishna, W. (2012) Retrotransposon insertions in rice gene pairs associated with reduced conservation of gene pairs in grass genomes. Genomics 99:308-14. Impact Factor 3.3
  • Dhadi SR, Deshpande A, Ramakrishna W. (2012) A novel nonwounding transient expression assay for cereals mediated by Agrobacterium tumefaciens.  Plant Molecular Biology Reporter 30:36-45. Impact Factor 1.7
  • Li K, Ramakrishna W. (2011) Effect of multiple metal resistant bacteria from contaminated lake sediments on metal accumulation and plant growth. Journal of Hazardous Materials 189:531-539. Impact Factor 4.5
  • Xu Z, Rafi S, Ramakrishna W. (2011) Polymorphisms and evolutionary history of retrotransposon insertions in rice promoters.  Genome 54:629-638. Impact Factor 1.7
  • Krom N, Ramakrishna W. (2011) Conservation, rearrangement, and deletion of gene pairs during the evolution of four grass genomes.  DNA Research 17:343-352. Impact Factor 5.5
  • Dhadi SR, Krom N, Ramakrishna W. (2009) Genome-wide comparative analysis of putative bidirectional promoters from rice, Arabidopsis, and Populus.  Gene 429:65-73.  Impact Factor 2.1
  • Krom, N, Ramakrishna W. (2008) Comparative analysis of divergent and convergent gene pairs and their expression patterns in rice, Arabidopsis, and PopulusPlant Physiology  147:1763-1773. Impact Factor 8
  • Krom, N, Recla J, Ramakrishna W. (2008) Analysis of genes associated with retrotransposons in the rice genome.  Genetica 134:297-310. Impact Factor 2.2
  • Xu Z, Ramakrishna W.  (2008)Retrotransposon insertion polymorphisms in six rice genes and their evolutionary history.  Gene 412:50-58.  Impact Factor 2.1
  • Oakley RV, Wang Y-S, Ramakrishna W, Harding SA, Tsai CJ. (2007) Differential expansion and expression of α- and β-tubulin gene families in Populus.  Plant Physiology 145:961-973. Impact Factor 8
  • Nagy E, Lee T-C, Ramakrishna W, Xu Z, Klein P, SanMiguel P, Cheng C-P, Li J, Devos K, Schertz K, Dunkle L, Bennetzen J.  (2007) Fine mapping of the Pc locus of Sorghum bicolor, a gene controlling the reaction to a fungal pathogen and its host-selective toxin. Theoretical Applied Genetics 114:961-970. Impact Factor 3.8
  • Gorantla M, Babu P, Reddy Lachagari V, Reddy A, Wusirika R, Bennetzen JL, Reddy AR.  (2007) Identification of stress-responsive genes in an indica rice (Oryza sativa L.) using ESTs generated from drought-stressed seedlings. Journal of Experimental Botany 58:253-265. Impact Factor 5.5
  • Lai J, Ma J, Swigonova Z, Ramakrishna W, Linton E, Llaca V, Tanyolac B, Park YJ, Jeong OY, Bennetzen JL, Messing J (2004) Gene loss and movement in the maize genome.  Genome Research 14:1924-1931.  Impact Factor 13.9
  • Swigonova Z, Lai J, Ma J, Ramakrishna W, Llaca V, Bennetzen JL, Messing J. (2004) Close split of sorghum and maize genome progenitors.  Genome Research 14:1916-1923. Impact Factor 13.9
  • Yan L, Loukoianov A, Blechl A, Tranquilli G, Ramakrishna W, SanMiguel P, Bennetzen JL, Echenique V, Dubcovsky J.  (2004) The wheat VRN2 gene is a flowering repressor down-regulated by vernalization. Science 303:1640-1644. Impact Factor 33.6
  • Bennetzen JL, Coleman C, Liu R, Ma J, Ramakrishna W (2004) Consistent over-estimation of gene number in complex plant genomes.  Current Opinion in Plant Biology 7:732-736. Impact Factor 7.9
  • Swigonova Z, Lai JS, Ma JX, Ramakrishna W, Llaca M, Bennetzen JL, Messing J. (2004) On the tetraploid origin of the maize genome. Comparative Functional Genomics 5:281-284. Impact Factor 2
  • Ramakrishna W, Deng Z, Ding CK, Handa AK, Ozminkowski RH Jr. (2003) A novel small heat shock protein gene, vis1, contributes to pectin depolymerization and juice viscosity in tomato fruit. Plant Physiology, 131:725-735. Impact Factor 8
  • Ramakrishna W, Dubcovsky J, Park Y-J, Busso C, Emberton J, SanMiguel P, Bennetzen JL.              (2002) Different types and rates of genome evolution detected by comparative sequence analysis of orthologous segments from four cereal genomes.  Genetics 162:1389-1400. Impact Factor 6
  • Ramakrishna W, Emberton J, Ogden M, SanMiguel P, Bennetzen JL. (2002). Structural analysis of the maize Rp1 complex uncovers numerous sites and unexpected mechanisms of local rearrangement.  Plant Cell 4:3213-3223. Impact Factor 10.5
  • Ramakrishna W, Emberton J, SanMiguel P, Ogden M, Llaca V, Messing J, Bennetzen JL. (2002) Comparative sequence analysis of the sorghum Rph region and the maize Rp1 resistance gene complex. Plant Physiology 130:1728-1738. Impact Factor 8
  • Bennetzen JL, Ramakrishna W. (2002) Numerous small rearrangements of gene content, order and orientation differentiate grass genomes.  Plant Mol Biol 48:821-827. Impact Factor 4.3
  • Yan L, Echenique V, Busso C, SanMiguel P, Ramakrishna W, Bennetzen JL, Harrington S, Dubcovsky J.  (2002) Cereal genes similar to Snf2 define a new subfamily that includes human and mouse genes. Molecular Genetics Genomics 268:488-499. Impact Factor 2.7
  • Stam M, Belele C, Ramakrishna W, Dorweiler JE, Bennetzen JL, Chandler VL. (2002) The regulatory regions required for B' paramutation and expression are located far upstream of the maize b1 transcribed sequences. Genetics 162:917-930. Impact Factor 6
  • Bennetzen JL, Ramakrishna W.  (2002)Exceptional haplotype variation in maize. Proceedings of the National Academy of Sciences USA 99:9093-9095. Impact Factor 9.7

Dr. Monisha Dhiman, Associate Professor
Peer-reviewed research publications

  • Dhiman, M. and Garg, N. J. (2014) P47phox-/- mice are compromised in expansion and activation of CD8+ T          cells and susceptible to Trypanosoma cruzi  infection. PLOS Pathogens. Impact Factor 8.4.
  • Kaur, N. Dhiman, M. Perez-Polo, J.R. and Mantha, A.K. (2015) Ginkgolide B Revamps Neuroprotective Role of APE1 and Mitochondrial OXPHOS Against Aβ(25-35)-Induced Neurotoxicity in Human Neuroblastoma Cells. Journal of Neuroscience Research. 9 Feb: DOI: 10.1002/jnr.23565. Impact Factor 2.7
  • Thakur, S. Sarkar, B. Cholia, R.P. Gautam, N. Dhiman, M. Mantha, A.K. (2014). APE1/Ref-1 as an Emerging Therapeutic Target for Various Human Diseases: Phytochemical Modulation of its Functions. Experimental Molecular Medicine. Jul 18(46): e106. doi: 10.1038/emm.2014.42. Impact Factor 2.46
  • Thakur, S. Dhiman, M. Tell, G. and Mantha, A.K. (2015). A Review on Protein-Protein Interaction Network of APE1/Ref-1 and its Associated Biological Functions. Cell Biochemistry & Function. 33(3):101-12. doi: 10.1002/cbf.3100. Epub 2015 Mar 19.Impact Factor 2.134
  • Dhiman, M. Wan, X. Popov, V. L. Vargas, G. Garg, N. J. (2013) MnSODtg Mice Control Myocardial Inflammatory and Oxidative Stress and Remodeling Responses Elicited in Chronic Chagas Disease. Journal of American Heart Association 2 (5): e000302 Impact Factor 5.8
  • Dhiman, M. Coronad, Y.A. Vallejo, C.K. Petersen, J.R. Ejilemele, A. Nuñez, S. Zago, M.P. Spratt, H. Garg, N.J. (2013) Innate immune responses and antioxidant/oxidant imbalance are major determinants of human Chagas disease. PLoS Negl Trop Dis. Aug; 7(8):e2364.  Impact Factor 4.8
  • Gupta, S. Wan, X. Zago, M. P.  Martinez, Sellers V.  Silva, T. S. Assiah, D. Dhiman, M. Nuñez, S.  Petersen, J. R. Vázquez-Chagoyán, J. Estrada-Franco, J. G. Garg, N. J. (2013) Antigenicity and diagnostic potential of vaccine candidates in human Chagas disease. PLoS Negl Trop Dis, 7(1):e2018 Impact Factor 4.8                                                       
  • Eaves-Pyles, T. Patel, J. Arigi, E. Cong, Y. Cao, A. Garg, N. Dhiman, M. Pyles, R.B. Arulanandam, B. Miller, A.L. Popov, V.L. Soong. L. Carlson, E. Coletta, C. Szabo, C. Almeida, I. (2013). Immunomodulatory and anti-bacterial effects of cystatin-9 against F. tularensis. Mol Med. Aug 2. doi: 10.2119/molmed.2013.00081.Impact Factor4.5
  • Gupta S, Wan X., Zago M. P,  Martinez Sellers V,  Silva T S, Assiah D, Dhiman M, Nuñez S, Petersen   J R, Vázquez-Chagoyán J, Estrada-Franco J G, Garg N J. (2013) Antigenicity and diagnostic potential of vaccine candidates in human Chagas disease. PLoS Negl Trop Dis 2013; 7(1):e2018 Impact Factor 4.8                 
  • Mantha AK, Dhiman M, Taglialatela G, Perez-Polo RJ, Mitra S. (2012) Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction. J Neurosci Res. Jun; 90(6):1230-9 Impact Factor 2.99
  • Dhiman M, Paola M. Zago, Sonia Nunez, Federico Nunez-Burgio and Nisha Jain Garg. (2012) Cardiac-oxidized Antigens Are Targets of Immune Recognition by Antibodies and Potential Molecular Determinants in Chagas Disease Pathogenesis. PLoS One 7; (1):e28449.   Impact Factor  3.8
  • Dhiman M and Garg NJ. (2011) Inhibition of NADPH-oxidase Attenuates T cruzi-induced Cardiac Pathology.  Journal of Pathology (2011) Dec; 225(4):583-96.  Impact Factor 7.2                                                                
  •  Jose´ E. Aparicio-Burgos, Laucel Ochoa-Garcıa, Jose´ Antonio Zepeda-Escobar, Shivali Gupta, Monisha Dhiman, Jose´ Simon Martınez, Roberto Montes de Oca-Jimenez, Margarita Val Arreola, Alberto Barbabosa-Pliego, Juan C. Vazquez-Chagoyan, Nisha Jain Garg (2011). Testing the Efficacy of a Multi-Component DNA-Prime/DNA-Boost Vaccine against Trypanosoma cruzi Infection in Dogs. PLoS Negl Trop Dis  5(5): 1-10. Impact Factor 4.8
  • Wen J-J, Gupta S, Guan Z, Dhiman M, Condon D, Lui CY, Garg NJ (2010). Phenyl-alpha-tert-butyl-nitrone and benzonidazole treatment controlled the mitochondrial oxidative stress and evolution of cardiomyopathy in chronic chagasic Rats. J Amer College Cardiology. 2010, 55(22):2499-508.   Impact Factor 16
  • Dhiman M, Jasmine Pando, Estrada-Franco JG, Aguilar FR, Corzo SB, Perez GM, Sandoval RG, Garg NJ. (2009) Increased myleoperoxidase activity and protein nitration are indicators of inflammation in chagasic patients. Clinical and Vaccine Immunology, 16(5):  660-666. Impact Factor3.08
  • Dhiman M, Nakayasu ES, Hosakote YM, Reynolds BK, Wen JJ, Almeida IC and Garg NJ. (2008) Enhanced Nitrosative Stress during Trypanosoma cruzi Infection Causes Nitrotyrosine Modification of Host Proteins. Implications in Chaga’s disease.  Am J Pathol.  173 (3): 728-740. Impact Factor 6.34
  • Wen J-J*, Dhiman M*, and Garg NJ. (2008) Tissue-specific oxidative imbalance and mitochondrial dysfunction during Trypanosoma cruzi infection in mice. Microbes Infect.  10 1201-1209. *Equal Contribution Impact Factor 3.0                                                          
  • Deep G, Dhiman M, Mendiz E, Rao AR and Kale RK. (2005) Chemo preventive Effects of Mustard Seeds in Chemically Induced Fore stomach and Uterine Cervix Tumors in Murine Model System. Human & Experimental Toxicology. 24 (6): 303-312.                  Impact Factor 2.78 
  • Deep G, Dhiman M, Rao AR and Kale RK. (2005). Chemopreventive Potential of Triphala on Benzo(a)Pyrene Induced Forestomach Tumorigenesis in Murine Tumor Model System. Journal of Experimental & Clinical Cancer Research.  24 (4) 555-563. Impact Factor 4.43  

                     
Book chapters

  • Dhiman M*,Thakur S, Upadhyay S, Kaur A and Mantha A K (2014) “Oxidative Stress and Inflammation in Cardiovascular Diseases: Two Sides of the Same Coin”. Free Radicals in Human Health and Disease, Oxidative Stress and Human Health. Springer publishers. *Corresponding author
  • Kaur N, Sarkar B, Mittal S, Dhiman M, Taglialatela G, Perez-Polo R.J., Mantha AK. (2014) “Oxidative Stress Events and Neuronal Dysfunction in Alzheimer’s Disease: Focus on APE1/Ref-1 Mediated Survival Strategies.” Free Radicals in Human Health and Disease, Oxidative Stress and Human Health. Springer publishers.
  • Gupta S, Dhiman M, Wen JJ, Garg NJ. (2011) ROS signaling of inflammatory cytokines during T. cruzi infection.  Advances in Parasitology. 76:153-70.

Dr. Somesh Baranwal, Assistant Professor
Peer-reviewed research publications

  • Dongdong Wang, Nayden G. Naydenov, Alex Feygin, Somesh Baranwal, John F. Kuemmerle, Andrei I. Ivanov. Actin-depolymerizing factor and cofilin-1 have unique and overlapping functions in regulating intestinal epithelial junctions and mucosal inflammation research article submitted to American Journal of Pathology. Impact Factor 4.59
  • Susana Lechuga, Somesh Baranwal, Andrei I. Ivanov. (2015) Actin interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions. Am J Physiol Gastrointest. Liver Physiol. 308 (9):G745-56. Impact Factor 3.72
  • Chetna Sharon, Somesh Baranwal, Nirmita J. Patel, Daniel Rodriguez-Agudo, William M. Pandak, Adhip PN Majumdar, Geoffrey Krystal, Bhaumik B. Patel. (2015) Inhibition of Insulin-like Growth Factor Receptor/AKT/Mammalian Target of Rapamycin Axis Targets Colorectal Cancer Stem Cells by Attenuating Mevalonate-Isoprenoid Pathway in vitro and in vivo. Oncotarget. 6(17):15332-47. Impact Factor 6.63
  • Susana Lechuga* , Somesh Baranwal*, Chao Li , Nayden G. Naydenov, John F. Kuemmerle, Vera Dugina , Christine Chaponnier, Andrei I. Ivanov (2014) Loss of  γ-cytoplasmic actin triggers myofibroblast transition of human epithelial Cell (* denotes equal contribution) Mol Biol Cell.  25(20):3133-46 Impact Factor 5.86.
  • Jagrut Patel*, Somesh Baranwal*, Ian Love, Nirmita Patel, Steven Grossman, Bhaumik B. Patel. Inhibition of C-terminal Binding Protein attenuates Transcription Factor 4 signaling to selectively target Colon Cancer Stem Cells. (* denotes equal contribution) Cell Cycle. 2014 Nov 15; 13(22):3506-18. Impact Factor 5.006
  • Patel, N*, Karuturi, Rajesh, Al-Horani, Rami*, Somesh Baranwal, Patel, Jagrut; Desai, Umesh; Patel, Bhaumik. (2014) Synthetic, Non-Saccharide Glycosaminoglycan Mimetics Selectively Target Colon Cancer Stem Cells (*denotes equal contribution) ACS Chem Biol. 9(8):1826-33. Impact Factor 5.44
  • Patel J*, Somesh Baranwal*, IM Love, NJ Patel, A Raqhibana, C Sharon, BB Patel (2014) C-Terminal Binding Protein is an important therapeutic target for Colorectal Cancer to Selectively aim at Cancer Stem Cells by regulating β-Catenin signaling., Gastroenterology 146 (5), S-516-S-517  (Abstract). Impact Factor 16.716
  • Patel NJ*, R Karuturi*, RA Al-Horani*, Somesh Baranwal, J Patel, UR Desai, BB Patel (2014) Synthetic, non-saccharide glycosaminoglycan mimetics selectively target colon cancer stem cells  Gastroenterology 146 (5), S-84-S-85  (Abstract). Impact Factor 16.716
  • Sharon Chetna, Somesh Baranwal, J Patel, NJ Patel, BB Patel.(2014) Inhibition of Insulin-Like Growth Factor Receptor Activity Attenuates Colon Cancer Stem Cells Growth and Self-Renewal by Targeting Mevlonate-Isoprenoid Metabolism, Gastroenterology 146 (5), S-692 (Abstract) Impact Factor 16.716
  • Dong S, Somesh Baranwal, M. Maziveyi, S. Alahari (2013) Nischarin-integrin interaction and downstream signaling regulate mouse mammary development and tumorigenesis Mol. Biol. Cell, December 15, vol. 24 # 888 (Abstract) Impact Factor 4.54
  • Nayden G. Naydenov*, Somesh Baranwal*, Shadab Khan, Alex Feygin, Pooja Gupta and Andrei I. Ivanov (2013) Novel mechanism of cytokine-induced disruption of epithelial barriers: janus kinase and protein kinase D dependent down regulation of junction protein expression Tissue Barriers. (*denotes equal contribution) Oct 1;1(4):e25231
  • Prachi Jain, Somesh Baranwal, Amanda P. Struckhoff, Rebecca A. Worthylake, Suresh K Alahari  (2013) LKB1 interacts with Nischarin to regulate breast tumor growth and metastasis. J Biol Chem.  288(22):15495-509. Impact Factor 4.77
  • Michael J. Walters*, Angela C. Brown*, Thomas C. Edrington, Somesh Baranwal, Yurong Du, Edward T. Lally, and Kathleen Boesze-Battaglia (2013) Contact with Membrane Lipids Induces Changes in Aggregatibacter actinomycetemcomitans Leukotoxin Secondary Structure. Mol Oral Microbiol.  28(5):342-53. Impact Factor 2.64
  • Somesh Baranwal, Nayden G. Naydenov, Gianni Harris, Vera Dugina, Kathleen G. Morgan, Christine Chaponnier, Andrei I. Ivanov (2012) Non-redundant roles of cytoplasmic beta- and gamma-actin isoforms in regulation of epithelial apical junctions Mol Biol Cell. 23(18):3542-53. Impact Factor 5.86
  • Nayden G Naydenov, Bryan Brown, Gianni Harris, Michael R Dohn, Victor M Morales, Somesh Baranwal, Albert B Reynolds, Andrei I. Ivanov (2012) A membrane fusion protein alpha-SNAP is a novel regulator of epithelial apical junctions   PLoS One. 7(4):e34320 Impact Factor 4.11
  • Somesh Baranwal, Wang Y, Rathinam R, Lee J, Jin L, McGoey R, Pylayeva Y, Giancotti F, Blobe GC, Alahari SK. (2011) Molecular characterization of the tumor-suppressive function of Nischarin in breast cancer.  J National Cancer Inst. 103 (20): 1513-28 Impact Factor 14.69
  • Prachi Jain, Somesh Baranwal, Suresh K Alahari, (2011) Tumor suppressor LKB1 cooperates with the integrin-binding protein Nischarin to inhibit breast cancer Cancer Research. 71(8 Supplement):2196-2196. (Abstract) Impact Factor 9.28.
  • Yanfang W*, Shenouda S*, Somesh Baranwal*, Rathinam, R. Jain P., Hazari S, Dash S, Alahari SK. (2011) Integrins alpha-5 and alpha-6 regulate cell cycle by modulating the Chk1 and Rb/E2F pathways to affect breast cancer metastasis. Molecular Cancer. 10:84. (*Denotes equal contribution) Impact Factor 5.4 .
  • Somesh Baranwal, Alahari SK (2011) Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis. Current Drug Targets.  12(8):1194-201. Impact Factor 3.081 .
  • Somesh Baranwal, Alahari SK. (2010) miRNA control of tumor cells invasion and metastasis. Int J Cancer. 126 (6): 1283-90. Impact Factor 5.44
  •  Somesh Baranwal, Alahari SK. (2009) Molecular mechanisms controlling E-cadherin expression in breast cancer.    Biochem.  Biophys.  Res.  Commun. 384 (1):6-11 Impact Factor 2.59
  • Somesh Baranwal, Walch A, Lakins J, Weaver VM and Alahari SK. Nischarin over expression inhibits metastasis by restoring epithelial markers in metastatic breast cancer cells Mol. Biol. Cell 19 (suppl), #. 1436/B655 (Abstract) Impact Factor 5.979
  • Wang, Y, Lavezzi, T, Walch Amelia, Milosavljevic T, Somesh Baranwal, S.K.  Alahari. December, (2007) “MicroRNA Profiling of Human Breast Cancer Cell Line MDA-MB-231 (sub-line 4175) and MCF10A. Mol. Biol. Cell 19 (suppl), #. 1436/B655 (Abstract) Impact Factor 5.57
  • Fong KP, Pacheco CM, Otis LL, Somesh Baranwal, Kieba IR, Harrison G, Hersh EV, Boesze-Battaglia K, Lally ET. (2006) Actinobacillus actinomycetemcomitans leukotoxin requires lipid micro domains for target cell cytotoxicity.  Cellular Microbiology 8(11): 1753-67. Impact Factor 5.62

Dr. Shashank Kumar, Assistant Professor
Peer-reviewed research publications

  • Bais S S, Lawrence K, Kumar S, Lawrence R (2015). Eichhornia crassipes (Mart.) Solm: A biotic resource for waste water treatment. World J Pharmaceut Sci. 3:1
  • Sanjay S S, Pandey A C, Kumar  S, Pandey A K. (2014).Membrane protective efficacy of ZnO nanoparticles,” OP Transactions on Nano-technology. 1:1, 21-29
  • Kumar S and Pandey AK. (2014). Medicinal attributes of S. xanthocarpum fruit consumed by several tribal communities as food: An antioxidant, anticancer and anti HIV perspective,” BMC Comp Alt Med, 14:112
  • Kumar S, Pandey S, Pandey A. K. (2014). In vitro antibacterial, antioxidant, cytotoxic activities of Parthenium hysterophorus and characterization of extracts by LC MS analysis. BioMed Research International (Formerly titled Journal of Biomedicine and Biotechnology). Article ID 495154
  • Kumar S, and Pandey A. K. (2014). Preliminary evaluation of biological activities and phytochemical analysis of Syngonium podophyllum leaf. National Academy Science Letters, 38:2, 143-146
  • Kumar S, Kumar R, Diwedi A, and Pandey A. K. (2014). In vitro antioxidant, antibacterial, cytotoxic activity and in vivo efficacy of Syngonium podophyllum and Eichhornia crassipes leaf extracts on isoniazid induced oxidative stress and hepatic markers. BioMed Res Int. 2014: Article ID 459452
  • Sharma A K, Kumar S and Pandey A K. (2014). Cell cycle inhibitory activity of Piper longum against A549 cell line and its protective effect against metal-induced toxicity in rats. Ind J Biochem Biophys. 2014, 51, October
  • Sharma A K, Kumar S and Pandey A K. (2014). Ferric reducing, antiradical and cytotoxic activites of Tinospora cordifolia stem extract. Biochem Anal Biochem. 3:2
  • Mishra A, Kumar S and Pandey AK. (2013). Scientific validation of the medicinal efficacy of Tinospora cordifolia,” Scientific World J, 2013, Article ID 292934.
  • Kumar S, Chashoo G, Saxena AK and Pandey AK, (2013). Parthenium hysterophorus: a probable source of anticancer, antioxidant and anti-HIV agent. BioMed Res Int., 2013: Article ID 810734
  • Mishra A, Sharma AK, Kumar S, Saxena AK and Pandey AK. (2013). Bauhinia variegata leaf extracts exhibit considerable antibacterial, antioxidant and anticancer activities. BioMed Res Int, 2013: Article ID 915436, 10 pages.
  • Kumar S, Gupta AK and Pandey AK. (2013) Calotropis procera root extract has capability to combat free radical mediated damage. ISRN Pharmacol, 2013: Article ID 691372
  • Kumar S, Mishra A, and Pandey AK. (2013) Antioxidant mediated protective effect of Parthenium hysterophorus against oxidative damage using in vitro models. BMC Comp Alt Med, 13:120
  • Kumar S, and Pandey AK.. (2013). Phenolic content, reducing power and membrane protective activities of Solanum xanthocarpum root extracts. Vegetos- An Int J Plant Res, 26, 301-307
  • Kumar S, Sharma UK, Sharma AK and Pandey AK. (2012). Protective efficacy of Solanum xanthocarpum root extracts against free radical damage: phytochemical analysis and antioxidant effect.  Cell Mol Biol, 58, 171-178.
  • Kumar S, and Pandey AK. (2012.) Antioxidant, lipo-protective and antibacterial activities of phytoconstituents present in Solanum xanthocarpum root. Int Rev Biophysical Chem, 3, 42-47
  • Mishra A, Kumar S, Bhargava, A, Sharma, B, and Pandey, A.K. (2011). Studies on in vitro antioxidant and anti staphylococcal activities of some important medicinal plants, Cell Mol Biol, 57, 16-25
  • Pandey A K, Mishra A, Kumar S, and Chandra, A. (2010). Therapeutic Potential of C. zeylanicum extracts: An antifungal and antioxidant perspective, Int J Biol Med Res. 1(4): 228-233
  • Kumar S and Pandey AK. (2015). Free radicals, from oxidative stress to disease and their mitigation by herbals, British J Med Med Res. 7 (6), 438-457
  • Kumar S and Pandey AK. (2014). Pharmacological activities of some common Indian weeds: A review, Mintage J Pharmaceut Med Sci, 3, 12-17
  • Kumar S, Gupta R, Kaleem AM, Pandey AK. (2014). Mitigation of pain and anesthetic drugs, OA Anaesthetics, 2 (1): 2
  • Pandey A K, and Kumar S. (2014) Perspective on plant products as antimicrobials agents: A review, Pharmacologia4: 469-480
  • Kumar S (2015). MicroRNAs an evolving prognostic, diagnostic and therapeutic target in prostate cancer. World J Pharmaceut Sci. 3:3, 387-389
  • Kumar R, Diwedi A, Kumar S and Pandey A. K. (2014) Effect of Eichhornia crassipes leaf aqueous extract on isoniazid induced oxidative stress and hepatic markers in albino wistar rats. In: Proceedings of All India Seminar on Recent Advances in Biotechnology and Human Health Care (March 2014). Editors R. Shrivastava, and B. Modhera, 1-7
  • Kumar S, and Pandey, AK, (2013) Phytochemicals analysis, cytotoxic and radical scavenging activities of Parthenium hysterophorus. In: Proceedings of Intl Conf on health, environment and industrial biotechnology (ICHEIB BioSangam 2013). Editor S. Sharma, McGraw Hill Education (India) Pvt Ltd., New Delhi. pp 271-274. ISBN (13): 978-9-33-290137-7

 Review Articles Published
1.  Kumar S, Ahamad MK, Waseem M, Pandey AK (2015). Drug targets for cancer treatment: An overview, Med Chem. 5:3, 115-123
2. Kumar S and Pandey AK. (2013). Chemistry and Biological Activities of Flavonoids: An Overview. Scientific World J, 2013,Article ID162750.
3. Kumar S (2014). Emerging trends in pharmaceutical sciences: An introduction. World J Pharmaceut Sci. 2:12, 1592-1593

Dr. Pramod Kushawaha, Assistant Professor
Peer-reviewed research publications

  • Kushawaha PK, Gupta R, Sundar S, Sahasrabuddhe AA and Dube A (2011). Elongation Factor-2- a Th1 stimulatory protein of Leishmania donovani generates strong IFN-γ and IL-12 response in cured Leishmania-infected patients/hamsters and protects hamsters against Leishmania challenge. J Immunol, 187: 6417–6427. Impact Factor-4.92
  • Kushawaha PK, Gupta R,  Tripathi CD,  Sundar S,  Dube A (2012): Evaluation of Leishmania donovani Protein disulfide isomerase as a potential immunogenic protein / vaccine candidate against visceral leishmaniasis. PLoS One, Volume 7/Issue 4/ e356770. Impact Factor-3.23
  • Kushawaha PK, Gupta R, Tripathi CD, Khare P, Jaiswal AK, Sundar S, Dube A (2012): Leishmania donovani Triose Phosphate Isomerase: a potential vaccine target against Visceral Leishmaniasis. PLoS One, Volume 7 | Issue 9 | e45766. Impact Factor-3.23
  • Gupta R *, Kushawaha PK *, Samant M, Jaiswal AK, Baharia AK, Dube A (2012). Treatment of Leishmania donovani- infected hamsters with miltefosine: analysis of cytokine mRNA expression by real- time PCR, lymphoproliferation, nitrite production and antibody response.  J Antimicrob Chemother. 2012 Feb;67(2):440-3.* Equally contributed. Impact Factor-5.33
  • Gupta R, Kushawaha PK, Tripathi CD, Sundar S, Dube A (2012): A novel recombinant Leishmania donovani p45-a partial coding region of methionine aminopeptidase protein generates protective immunity by inducing Th1 stimulatory response against experimental visceral Leishmaniasis. International Journal of Parasitology, May 1;42(5):429-35. Impact Factor-3.83
  • Samant M, Gupta R, Kumari S, Misra P, Khare P, Kushawaha PK,  Sahashrabuddhe AA, Dube A (2009).Immunization with the DNA Encoding N-terminal domain of Proteophosphoglycan (PPG) of Leishmania donovani generates Th-1 type immuno-protective response against Experimental Visceral Leishmaniasis. J Immunol Jul 1; 183(1):470-9. Impact Factor-4.92
  • Misra P, Khaliq T, Dixit A, SenGupta S, Samant M, Kumari S, Kumar A, Kushawaha PK, Majumder HK, Saxena AK, Narender T, Dube A (2008). Antileishmanial activity mediated by apoptosis and structure – based target study of Peganine hydrochloride, an approach for rational drug design. J Antimicrob chemother. Nov, 62 (5):998-1002. Impact Factor-5.33
  • Gupta R, Kumar V, Kushawaha PK, Tripathi CP, Joshi S, Sahasrabuddhe AA, Mitra K, Sundar S, Siddiqui I, Dube A (2014): Characterization of Glycolytic Enzymes - rAldolase and rEnolase of Leishmania donovani, Identified as Th1 Stimulatory Proteins, for Their Immunogenicity and Immunoprophylactic Efficacies against Experimental Visceral Leishmaniasis. PLoS One, 9(1): e86073. Impact Factor-3.23
  • Tripathi CD, Gupta R, Kushawaha PK, Mandal C, Misra Bhattacharya S, Dube A (2014). Efficacy of Withania somnifera chemotypes NMITLI - 101R, 118R and Withaferin A against experimental visceral leishmaniasis.  Parasite Immunology, 36, 253–265. Impact Factor-2.2
  • Jaiswal, Khare P, Joshi S, Kushawaha PK, Sundar S, Dube A (2014): Th1 stimulatory proteins of Leishmania donovani: Comparative cellular and protective responses of rTriose phosphate isomerase, rProtein disulfide isomerase and rElongation factor-2 in combination with rHSP70 against visceral leishmaniasis. PLoS One. Sep 30;9(9):e108556. Impact Factor-3.23

Papers Presented in Seminars/Conferences/Symposia/Workshops .

List of the Research Projects Operational in the Centre

  1. Dhiman, M. “Cardio-toxicity of the chemotherapeutic drugs” funded by Dept. of Science and Technology (DST), New Delhi. PI (22 Lakhs) (2013-16)
  2. Dhiman, M. “Molecular Mechanisms of Pollen-Mediated Stress in Human Epithelial Lung cell line” funded by Central University of Punjab as Research Seed Money (RSM). PI (3 Lakhs) (2014-16).
  3. Dhiman, M. “Mitochondrial Oxidative DNA Damage-Repair in Alzheimer’s disease: AP-endonuclease (APE1/Ref-1) as a Potential Therapeutic Target” funded by DST, New Delhi. Co-investigator (46 Lakhs).
  4. Somesh, B. “Role of Integrin binding protein, kindlin in colon cancer progression” funded by Dept. of Biotechnology (DBT). PI (82 Lakhs) (2015-2020)
  5. Pramod, K. “Functional characterization of the guanylate binding proteins- interferon- γ- inducible 65- KD GTPases in host immune response to Leishmania pathogenesis” funded by DST, New Delhi. PI (35 Lakhs)