School of Basic and Applied Sciences

Department of Biosciences


Centre for Biosciences started with the university's inception in 2009. At present, this centre is in the centrestage of university's research output, with six excellent research laboratories and a number of sophisticated research facilities. Research laboratories include Molecular Genetics Laboratory,Molecular Genetics Preparatory Laboratory, Animal Cell Culture Laboratory, Plant Tissue and Protoplast Culture Laboratory, Oxidative DNA Damage and Repair Laboratory and Biosciences teaching Laboratory. The centre at present has five internationally-trained and award-winning faculties. Over the years, the centre has won over 2.15 crores of external research grant, which is amongst the highest in the university. Major thrust areas of the centre include biodiversity and conservation genetics of plant and bacterial species, including trees, medicinal plants, desert and mountain flora, and seaweeds; abiotic stress tolerance in crop plants and gene regulation; Phylogenomics; and understanding pathobiology of human diseases such as cancer and Alzheimer's disease.

Faculty

  1. Prof. (Dr.) R.G. Saini (Center Coordinator)
  2. Dr. Felix Bast (Assistant Professor)
  3. Dr. Sanjeev K. Thakur (Assistant Professor)
  4. Dr. Anil Kumar Mantha (Assistant Professor)
  5. Dr. Pankaj Bhardwaj (Assistant Professor)

Academic Programmes Offered

  1. Integrated M.Phil.-Ph.D. Biosciences
  2. M.Sc. Biosciences
  3. M.Sc. Molecular Genetics

Syllabi

  1. Integrated M.Phil.-Ph.D. Biosciences
  2. M.Sc. Biosciences
  3. M.Sc. Molecular Genetics

Research Highlights

The centre is currently engaged in the study of DNA barcoding and the phylogenetic studies, DNA damage and repair, Development and characterization of genomic microsatellite markers in Rhododendron arboretum, Development and characterization of genomic microsatellite markers in Melia azedarach, Comparative Metagenomic Analysis and Isolation of Heavy Metal Resistant Bacteria from Agricultural Soil of Bathinda Region of Indian Punjab.

Laboratory Facilities
Centre for Biosciences features state-of-the-art scientific laboratories with some of the latest scientific infrastructure. Among the high-end equipment are Confocal Laser-Scanning Microscope with FCS, Field-Emission Scanning Electron Microscope, and 96 capillary Automated DNA Sequencer.

Equipment in lab

Equipment
Amount (in Rs.)
FESEM
238.98 Lacs
CLSM
161.39 Lacs
Green House and Screen House
9.43 Lacs
Incubator Shakers (2 units)
17.70 Lacs
Stackable CO Incubators
15 Lacs
Ice Flaking Machine
11.65 Lacs
Ultrapure Water Supply System
8.89 Lacs
 

Publication

  1. Bast, F. (2013). Seaweeds in Japanese culture: An analysis of medieval Waka poetry. The Phycologist (UK) 86: 24-27.
  2. Bast, F., Bhushan, S. and John, A. A. (2014). Morphological and molecular assessment of native carrageenophyte Hypnea valentiae (Cystocloniaceae, Gigartinales) in Indian Subcontinent. Phykos 44 (1): 52-58.
  3. Bast, F. (2014). Seaweeds: Ancestors of land plants with rich diversity. Resonance 19 (2): 1032-1043.
  4. Bast, F., Rani, P. and Meena, D. (2014). Chloroplast DNA phylogeography of holy basil (Ocimum tenuiflorum) in Indian subcontinent, The Scientific World Journal 847482.
  5. Bast, F. (2014). An Illustrated Review on cultivation and life history of agronomically important seaplants. In seaweed: Mineral composition, nutritional and antioxidant benefits and agricultural uses, (ed.), Vitor Hugo Pomin, Nova Publishers, New York (in press).
  6. Bast, F. (2013). Sequence-based phylogeography of seaweeds: How current distribution is shaped by accumulation of past? Kuroshio Science (Japan) 7 (1): 103-106.
  7. Singh, P. and Bast, F. (2013). Insulin receptor (IR) and insulin-like growth factor receptor 1(IGF-1R) Signaling systems: Novel treatment strategies for cancer. Medical Oncology. 31: 805.
  8. Bast, F. (2013). Agronomy and cultivation methods for edible seaweeds. Int. J. Agriculture and Food Science Technology. 4 (7): 661-666.
  9. Singh, P. and Bast, F. (2013). Multitargeted molecular docking study of plant-derived natural products on Phosphoinositide-3 Kinase pathway components. Medicinal Chemistry Research. DOI: 10.1007/s00044-013-0774-2
  10. Bast, F. (2013). Sequence similarity search, multiple sequence alignment, model selection, distance matrix and phylogeny reconstruction. Nature Protocol Exchange. (IF: 7.96) Nature Publishing Group. DOI: 10.1038/protex.2013.065 Accessible at: http://www.nature.com/protocolexchange/protocols/2740.
  11.  Suresha, G. S., Kumar, S., and Santha, I. M. (2013). Functional expression of Brassica juncea oleate desaturase gene (Bjfad2) in Escherichia coli. Biologia, 68 (4): 599-605.
  12.  Baviskar, A. T., Banerjee, U. C., Gupta, M., Singh, R., Kumar, S., Gupta, M. K. and Singh, S. (2013). Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity. Bioorganic and Medicinal Chemistry. 21 (18): 5782-5793.
  13. Suresha, G. S., Jacab, J., Bose, P., Kumar, S., and Santha, I. M. (2013). Molecular cloning of partial genomic DNA and cDNA sequence of Oleate Desaturase gene from Brassica juncea. Indian Journal of Agricultural Biochemistry, 26 (2): 125-129.
  14. Mantha, A. K., Sarkar, B. and Tell, G. (2013). A short review on the implications of base excision repair pathway for neurons: Relevance to neurodegenerative diseases. Mitochondrion, DOI: 10.1016/j.mito.2013.10.007.
  15. Mantha, A. K. (2013). APE1: A molecule of focus with neuroprotective and anti-cancer properties. Journal of Biotechnology and Biomaterials, 3 (3) 8 Pages.
  16. Bhardwaj, P., Kumar, R., Sharma, H., Tewari, R., Ahuja, P. S. and Sharma, R. K. (2013). Development and utilization of genomic and genic microsatellite markers in Assam tea (Camellia assamica spp. Assamica) and related Camellia species. Plant Breeding 132: 748-763.
  17. Bhardwaj, P., Sharma, R. K., Kumar, R., Sharma, H. and Ahuja, P. S. (2014). SSR marker based DNA fingerprinting and diversity assessment in superior tea germplasm cultivated in western Himalaya. Proceedings of Indian National Science Academy 80: 157-162.

Papers Presented in Seminars/Conferences/Symposia/Workshops

  1. Bast, F. (2014). Strong endemism of bloom-forming tubular ulva in Indian west coast, with description of Ulva paschima sp. nov. (Ulvales, Chlorophyta). National Conference on Recent Advances in Algology, Mycology and Plant Pathology at University of Madras Guindy Campus, February 19-20, 2014.
  2. Bast, F. (2013). Sargassum zhangii invades India. National Conference on Climate Change, Environmental and Sustainable Development at Jamia Hamdard, New Delhi, December 9-10, 2013.
  3. Bast, F. (2013). Agronomy and cultivation methods for edible seaweeds. 2nd International Conference on Agriculture, Food Technologies and Environment - New Approaches (AFTENA- 2013) at JNU, New Delhi, October 2013.
  4. Bast, F. (2013). British Phycological Society annual workshop on molecular phylogenetics of seaweeds at Marine Biological Association, Plymouth, March 13-15, 2013.
  5. Mantha, A. K., Kaur, N., Kaur, M. and Dhiman, M. (2013). Oxidative Stress Induced Modulation of SOD and APE1: Key towards survival of glioblastoma cells. Allahabad, October 24-27, 2013.
  6. Mantha, A. K., Dhiman, M. and Taglialatela, G. Amyloid beta induced gentotoxicity: what protects neurons? Cuttack, November 9-11, 2013.

List of the Research Projects Operational in the Centre

  1. Bast, F. Chemical and phylogenetic diversity of seaweeds from the Indian Subcontinent, funded by INSPIRE Faculty Award, Department of Science and Technology, Ministry of Science and Technology, Government of India, New Delhi. (Rs. 35 Lac). (2012-17)
  2. Bast, F. Genotoxicity detection in drinking water from Malwa region, Punjab, funded by University Grants Commission, Basic Science Research Start-Up Grant (Rs. 6 Lac). (2012-14)
  3. Mantha, A. K. APE1/Ref-1’s dual functions countering Beta Amyloid induced genotoxicity, from Alzheimer’s Association, USA (US $ 99,990). (2012-2014)
  4. Kumar, S. Investigating the mechanisms associated with temperature stress tolerance imposed by non lethal stress conditions; understanding metabolic relationship between drought x cold and drought x heat stress in chickpea (Cicer arietinum L.), Basic Science Research Start-Up Grant (Rs. 6 Lac). (2013-15)
  5. Bhardwaj, P. Analysis of genetic variations and structure of Rhododendron, a rare and endangered tree species in western Himalaya, funded by Department of Science and Technology, Ministry of Science and Technology, Government of India, New Delhi. (Rs. 16 Lac). (2013-16)
  6. Mantha, A. K. Apurinic/Apyrimidinic endonuclease (APE1) as an anti-cancer therapeutic agent for Glioblastoma therapy funded by University Grants Commission, New Delhi under the Basic Science Research Start up Grant (Rs. 6 Lac). (2013-15)

List of the Projects Approved

  1. Mantha, A. K. (PI) Mitochondrial Oxidative DNA damage-repair in Alzheimer’s Disease: AP-endonuclease (APE1/Ref-1) as a potential therapeutic target, from the Department of Science and Technology, Ministry of Science and Technology,Government of India, New Delhi, under the Cognitive Science Research Initiative, CSI-2012 (Rs. 46 Lac). (2014-17)
  2. Bast, F. Phylogenetic selection of target taxa for anti-proliferative and anti-metastatic marine natural products from seaweeds of Indian Coast. Funded by Drugs from Sea programme, Ministry of Earth Sciences, Government of India, New Delhi. (Rs. 91.06 Lac). (2014-17)
  3. Bast, F. Sequence-based DNA Barcoding, phylogeography and conservation genetics of selected medicinal plants from Indian Subcontinent, funded by Research Seed Money programme, Central University of Punjab, Bathinda (Rs. 3 Lac). (2014-15)
  4. Bhardwaj, P. Development and characterization of simple sequence repeat markers providing genome wide coverage and high resolution in Rhododendron arboretum funded by University Grants Commission, New Delhi under Basic Science Research Start up Grant (Rs. 6 Lac). (2014-16)

List of the Projects Approved

  1. Mantha, A. K. (PI) Mitochondrial Oxidative DNA damage-repair in Alzheimer’s Disease: AP-endonuclease (APE1/Ref-1) as a potential therapeutic target, from the Department of Science and Technology, Ministry of Science and Technology,Government of India, New Delhi, under the Cognitive Science Research Initiative, CSI-2012 (Rs. 46 Lac). (2014-17)
  2. Bast, F. Phylogenetic selection of target taxa for anti-proliferative and anti-metastatic marine natural products from seaweeds of Indian Coast. Funded by Drugs from Sea programme, Ministry of Earth Sciences, Government of India, New Delhi. (Rs. 91.06 Lac). (2014-17)
  3. Bast, F. Sequence-based DNA Barcoding, phylogeography and conservation genetics of selected medicinal plants from Indian Subcontinent, funded by Research Seed Money programme, Central University of Punjab, Bathinda (Rs. 3 Lac). (2014-15)
  4. Bhardwaj, P. Development and characterization of simple sequence repeat markers providing genome wide coverage and high resolution in Rhododendron arboretum funded by University Grants Commission, New Delhi under Basic Science Research Start up Grant (Rs. 6 Lac). (2014-16)